Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues.
نویسندگان
چکیده
Precursor-directed biosynthesis of calcium dependent antibiotics (CDAs) with modified 3-trifluoromethyl and 3-ethyl glutamate residues was achieved by feeding synthetic glutamate analogues to a mutant strain of Streptomyces coelicolor impaired in the biosynthesis of the natural precursor (2S,3R)-3-methyl glutamic acid.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 26 شماره
صفحات -
تاریخ انتشار 2007